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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RAPGEF6 All Species: 22.42
Human Site: S726 Identified Species: 70.48
UniProt: Q8TEU7 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TEU7 NP_057424 1601 179407 S726 M P I P G T L S S S S P D L L
Chimpanzee Pan troglodytes XP_001161644 1601 179429 S726 M P I P G T L S S S S P D L L
Rhesus Macaque Macaca mulatta XP_001101427 1601 179534 S726 M P I P G T L S S S S P D L L
Dog Lupus familis XP_849936 1459 165157 V611 F G I F V E G V E P S S K A A
Cat Felis silvestris
Mouse Mus musculus Q8CHG7 1138 126080 E290 F A V T A T P E Q Y S L C E V
Rat Rattus norvegicus NP_001100473 1606 179816 S726 M P I P G T L S S S S P D L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510849 1610 181536 S757 M P I P G T L S S S S P D L L
Chicken Gallus gallus XP_420387 1661 185877 S765 L P V S G T L S S S N P D L L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 98.3 78.6 N.A. 42.1 90.8 N.A. 78.7 61.8 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 99 83 N.A. 51.2 95.1 N.A. 86.6 73.5 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 13.3 N.A. 13.3 100 N.A. 100 73.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 13.3 N.A. 26.6 100 N.A. 100 93.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 0 0 13 0 0 0 0 0 0 0 0 13 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 75 0 0 % D
% Glu: 0 0 0 0 0 13 0 13 13 0 0 0 0 13 0 % E
% Phe: 25 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 13 0 0 75 0 13 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 75 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % K
% Leu: 13 0 0 0 0 0 75 0 0 0 0 13 0 75 75 % L
% Met: 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 13 0 0 0 0 % N
% Pro: 0 75 0 63 0 0 13 0 0 13 0 75 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 13 0 0 0 75 75 75 88 13 0 0 0 % S
% Thr: 0 0 0 13 0 88 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 25 0 13 0 0 13 0 0 0 0 0 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 13 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _